Nanotechnology has been instrumental in promoting certain valuable innovations in the manufacturing of drugs and drug delivery systems.
Non-invasive, micellar nanoparticle technology is known to deliver the drug encapsulated in tiny emulsion particles right into the skin. The micellar nanoparticles get deposited in the outermost skin layer while rubbing, thereby functionally producing a drug depot. The emulsion deposits the active drug into the epidermis and stratum corneum. Gradually, the drug diffuses into the deeper layers of the skin till it reaches the blood stream. Estrasorb, developed by Novavax, is one product that uses this nanoparticle technology to deliver estrogen in a lotion product to be used for treating the symptoms of menopause.
The nanocrystal technology innovated by Elan enables the formulation of compounds that are poorly water soluble besides improving their compound activity and final product characteristics. Interestingly, their NanoCrystal Ò technology can be introduced into all dosage forms both oral and parenteral and oral, also including liquid, solid, fast-melt, controlled release and pulsed release forms. The principle involved in this technology is quite interesting. Poor water solubility causes slow dissolution rate. Therefore, decreasing the size of particles shall increase the surface area, leading to a dramatic increase in the rate of dissolution. This is what is achieved by efficiently by employing NanoCrystal Ò technology. NanoCrystal Ò particles are tiny particles of drug substance, amazingly lesser than 1000 nanometers (nm) in diameter. They are produced through wet-milling technique. The NanoCrystal Ò particles forming part of the drug are ably stabilized against agglomeration through surface absorption of selected stabilizers. The resulting aqueous dispersion substance clearly behaves like a solution that can be further processed into finished dosage forms for all modes of administration.
BioSilicon, from Psvidia, is an amazingly simple product used as advanced drug delivery system. Despite the delivery characteristics imparted by the process of nanostructuring, the product does not require complex chemistry unlike most polymer-based drug delivery systems. The final product is pure silicon. The product has an additional advantage over several others in terms of its radiation and heat stability, thereby simplifying sterilization and manufacturing.
Subscribe to:
Post Comments (Atom)
1 comment:
This blog provides nanoparticle technology,Nanocrystal technology and Biosilicon are three technique used as drug delivery system..very interesting and useful blog.
To overcome the problems of gene and drug delivery,nanotechnology has gained interest in recent years.Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications.Global Market Research
Post a Comment